2006 INDUCTEE Hans Selye, MD PhD Hormones

Born:

January 26, 1907

(Vienna, Austria)

Died:

October 16, 1982

Education:

MD: German University of Prague (1929)
PhD: German University of Prague
DSc: McGill University

Awards & Honours:

1976: Golden Plate Award, American Academy Achievement

1968: Companion of the Order of Canada

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Introduced the concept of stress to medical research and treatment

The father of biological stress research

Dr. Selye’s initial discovery of the stress syndrome was based on the demonstration that the body nonspecifically responded in virtually the same way to various innocuous stimuli or stressors. During his medical studies, he had previously observed that patients with various illnesses appeared to display the syndrome of being sick. One of his greatest contributions was the demonstration of the stress triad (gastrointestinal ulceration, thymico-lymphatic atrophy and adrenal hypertrophy) and of the role of the hypothalamus in stimulating the hypophysis, which induced the adrenals to produce corticoids. These descriptions led to the discovery of the steroids ACTH, GRH, somatostatin and other hypothalamic and hypophyseal releasing factors and hormones. Collectively these discoveries described the body’s internal stress-processing mechanism.

Key Facts

Revolutionized our understanding of the causes and mechanisms of disease with his theories on the roles of organic responses to emotion, illness and injury

Advanced his theory of “General Adaption Syndrome” that suggests stress plays a role in every disease

Pioneered concepts of adaptation energy, stress hardiness, post traumatic growth, and codes of behaviour that were protective of life stressors.

Collaborated in designing a conceptual model for stress education and intervention that was multidisciplinary holistic and integrative

Published more than 1,700 articles and 39 books on stress and has been cited in over 362,000 publications

Became an Honorary Fellow of 69 scientific societies

Professional timeline

Impact on lives today

While Dr. Selye worked strictly with animals and never saw a patient, his research created a body of medical knowledge that continues to have a profound impact today. His theory of General Adaptation Syndrome allows physicians to better understand, predict, and treat symptoms of stress including ulcers, high blood pressure and heart attacks. Moreover, his concept of stress has developed into a flourishing field of research that has expanded our knowledge of how stress influences numerous biological responses. In addition, patients who suffer from hypertensions can feel the impact of his discovery of the anti-inflammatory effects of steroids. Importantly, Dr. Seyle not only provided the scientific foundation for future development, he also mentored the next generation of stress researchers. Among these former students are Nobel Prize Laureate Roger Guillemin and Canadian Medical Hall of Fame Laureate Claude Fortier.

2006

April 26, 2006
Hans Selye posthumously inducted into the Canadian Medical Hall of Fame

Edmonton, Alberta
1979
The International Institute of Stress was founded
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Dr. Selye also established the Hans Selye Foundation in the same year.
1976
"Stress in Health and Disease" was published
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1974
Dr. Hans Seyle published "Endocrinology"
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This textbook remained a reference classic for many years.
1956
"The Stress of Life" was published
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This work, along with "Stress Without Distress" (1974) became international best sellers. They also represent Dr. Selye’s commitment to public education regarding practical applications of stress research.
1955
Dr. Hans Selye published “Stress and Disease” in Science
Hormones
In this article, he proposed that deficient host defense due to abnormalities of neuroendocrine factors may lead to disease.
1945
Dr. Seyle transferred to the Université de Montréal.
Leadership in Organizational Development
At UM, he founded and became Director of the Institute of Experimental Medicine and Surgery. He held this position until his retirement in 1977.
1936
Dr. Hans Seyle presented his concept of stress in the science journal, Nature
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In the article, he described stress as “a syndrome produced by diverse noxious agents.” He also included a description of General Adaptation Syndrome and its three stages of alarm, resistance and exhaustion.
1932
Dr. Seyle came to Canada to carry out research at McGill University
Health and Medical Education & Training, Hormones
He studied under the direction of J.B. Collipp who discovered the Parathyroid hormone. The following year, Dr. Seyle was recruited to McGill as an Assistant Professor.
~ 1927
Dr. Hans Selye began developing his theories on stress as a medical student in Prague
Hormones