1997 INDUCTEE Robert Noble, MD PhD Cancer

Born:

February 3, 1910

(Toronto, Ontario)

Died:

December 11, 1990

Education:

MD, University of Toronto (1934)
PhD, University of London (1937)

Awards & Honours:

1988: Officer of the Order of Canada

1984: Gairdner Foundation International

Picture of Robert Noble, MD, PhD

Discovered vinblastine

Robert Noble

An esteemed Canadian investigator and ingenious experimentalist
 

In 1952, Dr. Noble received an envelope that had 25 periwinkle leaves enclosed. The envelope was sent to him by his brother, Dr. E. Clark Noble, a diabetes researcher at the time. From the leaves, Dr. Noble developed a concentrated extract and injected it into laboratory rats. The rats all died due to infection, which Noble would discover was caused by a significant reduction of white blood cells. Although the extract had little effect on blood sugar levels, it held promise for cancer treatment. Joined by Dr. Charles Beer, Dr. Noble made the ground breaking discovery of vinblastine.  While not a cure, in combination with other drugs, vinblastine had a major impact on controlling the growth of a number of different types of cancers.

Dr. Noble and Dr. Charles Beer were jointly nominated and inducted into the Canadian Medical Hall of Fame.

 

Key Facts

Published over 200 articles

Vinblastine was the first major Canadian advance in cancer chemotherapy

At the time of its discovery, vinblastine was the most effective treatment available for Hodgkin’s lymphoma

Established the Cancer Research Group UBC, which attracted an influx of prominent faculty members

Honoured with the Robert L. Noble Prize, a prestigious award that is granted annually by the National Cancer Institute of Canada

Professional timeline

Impact on lives today

Today, vinblastine is still widely used in conjunction with other drugs to treat various forms of cancer, including non-small cell lung cancer, melanoma, and breast, bladder, brain and testicular cancers. It remains a primary treatment for Hodgkin’s disease, and is also used to treat histocytosis, a characteristic component of a group of rare diseases that previously had limited therapeutic options.  

Picture of Robert Noble, MD, PhD

1997

  • Robert Noble posthumously inducted into the Canadian Medical Hall of Fame

    London, Ontario

  • Despite his official retirement in 1975, Noble remained committed to science

    He became an Honorary Member of the BC Cancer Agency in the Division of Cancer Endocrinology where he continued his research until his death in 1990.

  • Noble was appointed Director of Cancer Research and Professor of Physiology at the University of British Columbia

    At UBC, he continued pioneering research and mentored future scientists.

  • Vinblastine sulfate injection

    The purification process of vinblastine was patented in the name of Drs. Beer, Noble and doctoral student Dr. J.H. Cutts

    Cancer

    The drug was made widely available in partnership with the university and the Eli Lilly Company, significantly impacting the lives and treatment of millions of cancer patients worldwide.

  • Noble and his team worked with Dr. Harold Warick in Toronto and Mr. Mac Whitelaw in Vancouver to initiate human clinical trials

    Within two years, this Canadian team had announced the successful results of their study.

  • Dr. Charles Beer joined Noble’s research team

    Cancer

    The combination of their skills and expertise led to the isolation and purification of “vinblastine” in 1958.

  • Noble’s research focused on potential anti-diabetic properties of the periwinkle plant extract, however, he confirmed that it had little effect on the blood sugar levels of experimental rats

    Laboratory technologist Halina Czajkowska observed, however, that the extract destroyed the rats’ white blood cells and bone marrow. This finding raised the possibility that the extract could be used to treat leukemia, a cancer characterized by high counts of abnormal white blood cells.

  • Vinca Rosea 2

    Dr. C.D. Johnson, a graduate of McGill University who lived in Jamaica, hypothesized that properties of the periwinkle plant had an anti-diabetic component.

    Johnson sent samples of the plant to Dr. E. Clarke Noble for further investigation.

  • Noble joined the University of Western Ontario

    In 1947, he was appointed Associate Director of the Collip Medical Research Laboratory.

  • After completing his MD at the University of Toronto, Noble pursued his PhD at University of London

    He then returned to Canada and worked alongside the revered Dr. J. B. Collip at McGill University, where he focused his research on endocrine-related cancers.

1937

He was a skilled and ingenious experimentalist.